Haematobiochemical Changes In Albino Rats Infected With <i>Trypanosoma Brucei Brucei </i>

Abstract

Some haematological and biochemical implications of Trypanosoma brucei infection was studied using Wistar albino rats. The haematological parameters studied are the white blood cell (WBC) count, which was used as an index of the presence and level of infection, and packed cell volume (PCV) which was used as an index of the presence and level of anaemia, while biochemical parameters assayed are sodium ions (Na+), potassium ions (K+), bicarbonate ions (HCO-3) and urea. These analyses were carried out on both experimental and control groups. there was an increase in WBC count in rats infected with trypanosomes and an associated decrease in PCV. Although all the biochemical parameters were observed to be on the increase in the infected groups than in the control group the analysis of variance (ANOVA) of these findings showed that they are statistically insignificant at P=0.05.

Nigerian Quarterly Journal of Hospital Medicine Vol.9, No.3 (1999) pp. 238-240