PROMOTING ACCESS TO AFRICAN RESEARCH

Nigerian Quarterly Journal of Hospital Medicine

Log in or Register to get access to full text downloads.

Remember me or Register



DOWNLOAD FULL TEXT Open Access  DOWNLOAD FULL TEXT Subscription or Fee Access

Alcohol Consumption and Viral Hepatitis in Chronic Liver Disease in Lagos

O A Lesi, K O Kehinde, E E Amomneze

Abstract




Background: Precise assessment of the risks and interactions of alcohol consumption and viral hepatitis in the aetiology of chronic liver disease [CLD] are not locally available.
Methodology: 74 patients with CLD and 74 controls were evaluated for Hepatitis B and C infection [anti-HCV, HBsAg]. The type and amount of alcohol consumed was ascertained using a questionnaire and the percentage alcohol content was calculated and reported in grams.
Results: Significant alcohol consumption increases the risk of both liver cirrhosis and hepatocellular carcinoma. [OR=4.7, p=0.03 and OR=8.l, p=0.001 respectively]. Persons chronically infected with HBV who drink alcohol regularly have a 23 fold risk of CLD [p=<0.001] compared with subjects who either drinks [3 fold, p=0.02] or is HBV infected [7 fold, p=0.0001].
Conclusion: Alcohol is an independent risk factor for CLD and appears to act in synergy with viral hepatitis B infection to potentate the risk of chronic liver disease.


NQJHM Vol. 14 (1) 2004: pp. 5-7



http://dx.doi.org/10.4314/nqjhm.v14i1.12666
AJOL African Journals Online