PROMOTING ACCESS TO AFRICAN RESEARCH

Orient Journal of Medicine

Log in or Register to get access to full text downloads.

Remember me or Register



DOWNLOAD FULL TEXT Open Access  DOWNLOAD FULL TEXT Subscription or Fee Access

Can serum concentration of C-reactive protein, albumin and body weight serve as an index of disease progression and treatment assessment in HIV/AIDS subjects?

AO Oluboyo, UN Onyekachi, CC Onyenekwe, BO Oluboyo, RC Chukwuanukwu, CNC Odiegwu, GO Chukwuma, UF Onwuasoanya, AO Onyemelukwe

Abstract


Background: Human immunodeficiency virus infection induces an acute phase response which is marked by changes in the plasma concentrations of acute phase proteins and a fall in CD4+T-cell counts and body weight.
Objective: To determine whether serum concentration of C-reactive protein, serum albumin level and body weight can serve as an index of disease progression and treatment assessment in HIV/AIDS. Methodology: The study investigated 80 subjects (40 subjects on anti-retroviral therapy and 40 not on therapy) and 40 sero-negative subjects (control) attending the HIV/AIDS Clinic in Nnamdi Azikiwe Teaching Hospital, Nnewi, Nigeria. We determined serum concentrations of C-reactive protein, serum albumin levels and body weights. The C-reactive protein was estimated using semi-quantitative method, albumin level was estimated using bromocresol green method, and biuret method was used for total protein. The CD4+T-cell count of the subjects was determined using CyFlow Analyzer while their weights were measured using high precision weighing balance.
Results: We observed that the mean weight (Kg), CD4+T-cells count (count/mm3), serum albumin (g/L), and total protein (g/L) of HIV subjects on therapy and those not on therapy were significantly lower (p<0.05) than in the control subjects. The mean C-reactive protein (mg/dL) was significantly higher in subjects on therapy compared to those not on therapies and the control subjects, p<0.05.
Conclusion: In resource-poor regions or remote areas or villages where CD4+T-cell counts and viral load tests may not be available, the concentration of C-reactive protein, serum albumin level and changes in weight may serve as a reliable alternative marker for disease progression and treatment assessment for HIV subjects.

Keywords: Acute-phase proteins, anti-retroviral therapy, total protein




AJOL African Journals Online