Arterial compliance in a group of normotensive and untreated hypertensive Cameroonian subjects in Yaounde

  • Samuel Kingue
  • Joshua Walinjom
  • Alain Menanga
  • Pierre Mintom
  • Marie Ntep Ngweth
  • Fesuh Betrand
  • Walinjom Muna

Abstract

Introduction: Arterial compliance is an independent predictor of cardiovascular events. It decreases with age and this decrease is accelerated by hypertension. The objectives were to determine the arterial compliance in a group of normotensive and untreated hypertensive stage 1, 2 and 3 Cameroonian subjects. Methods: A cross-sectional study was conducted from August 2012 to February 2013 in Yaoundé. Our sample size was 88 participants. The PulsePen® device was used to determine cfPWV (carotid-femoral Pulse Wave Velocity) and central Augmentation Index % (AIx). Other measurements obtained were: blood pressure (BP), body mass index (BMI), fasting glycaemia, lipid profile and serum creatinine. Results: Our sample's mean age was 35.48 years and ranged from 20 to 60 years. The means of: cfPWV, SBP, DBP, Pulse Pressure (PP) and Heart Rate (HR) showed a statistically significant increase (p-value < 0.05) across the groups from normotensive to severely hypertensive patients. cfPWV was significantly correlated (p-value< 0.05) to: Age, Central SBP, Central DBP, Central PP, HR, BMI and central Augmentation index (AIx). Furthermore, cfPWV was significantly dependent on LVH (p-value <0.05). Conclusion: This study suggests that arterial compliance decreases with increase severity of hypertension, indicating a higher risk of developing cardiovascular events in severely hypertensive patients.

Pan African Medical Journal 2016; 24

Author Biographies

Samuel Kingue
Medical & cardiology Unit, General Hospital Yaoundé, Cameroon
Joshua Walinjom
Faculty of Medicine and Biomedical sciences, University of Yaoundé I, Cameroon
Alain Menanga
Medical & cardiology Unit, General Hospital Yaoundé, Cameroon
Pierre Mintom
Medical & cardiology Unit, General Hospital Yaoundé, Cameroon
Marie Ntep Ngweth
Medical Unit, Central Hospital Yaoundé, Cameroon
Fesuh Betrand
National Advanced School of Engineering, Department of mathematics, Physics and Applied Statistics,University of Yaoundé 1, Cameroon
Walinjom Muna
Medical & cardiology Unit, General Hospital Yaoundé, Cameroon
Published
2016-09-18
Section
Articles

Journal Identifiers


eISSN: 1937-8688