Secondary severe thrombocytosis in a patient who underwent splenectomy due to hereditary spherocytosis and its treatment using hydroxyurea

  • Hakan Sarbay Diyarbakir Children Hospital, Pediatric Hematology and Oncology, Turkey
  • Sinan Akbayram Gaziantep University Faculty of Medicine, Pediatric Hematology and Oncology, Turkey
Keywords: Hydroxyurea; thrombocytosis; splenectomy


Thrombocytosis is a frequently seen condition during childhood. While it usually develops secondarily due to reasons such as infection or anemia, it may rarely develop due to clonal causes. Thrombocytosis becomes a life-threatening condition by causing severe complications such as hemorrhage and thrombosis development. Treatment is not recommended in patients who are asymptomatic and with a platelet count below 1,500,000/mm3, however, treatment is required in cases who are symptomatic and with a platelet count above 1,500,000/mm3 in conditions such as primary thrombocytosis. This article present the outcomes of a patient who was treated using low-dose hydroxyurea when he developed severe thrombocytosis after splenectomy.


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eISSN: 1937-8688