Djiba Kaba
Université Gamal Abdel Nasser de Conakry, Conakry, Guinée; Laboratoire de Biologie Moléculaire Nestor Bangoura/Hélène Labrousse, CTA Hôpital National Donka, Conakry, Guinée
Mmah Aminata Bangoura
Université Gamal Abdel Nasser de Conakry, Conakry, Guinée, Service de Pédiatrie de l’Hôpital National Donka, Conakry, Guinée
Mariame Moustapha Sylla
Service de Pédiatrie de l’Hôpital National Donka, Conakry, Guinée
Fodé Bangaly Sako
Université Gamal Abdel Nasser de Conakry, Conakry, Guinée; Service des Maladies Infectieuses et Tropicales de l’Hôpital National Donka, Conakry, Guinée
Mariama Sadjo Diallo
Université Gamal Abdel Nasser de Conakry, Conakry, Guinée; Laboratoire de Biologie Moléculaire Nestor Bangoura/Hélène Labrousse, CTA Hôpital National Donka, Conakry, Guinée
Issiaga Diallo
Université Gamal Abdel Nasser de Conakry, Conakry, Guinée; Laboratoire de Biologie Moléculaire Nestor Bangoura/Hélène Labrousse, CTA Hôpital National Donka, Conakry, Guinée
Ouo-Ouo Yaramon Kolié
Laboratoire de Biologie Moléculaire Nestor Bangoura/Hélène Labrousse, CTA Hôpital National Donka, Conakry, Guinée
Ahmed Sékou Keita
Service de Dermatologie-Vénéréologie, Hôpital National Donka, Conakry, Guinée
Boh Fanta Diané
Université Gamal Abdel Nasser de Conakry, Conakry, Guinée; Service de Dermatologie-Vénéréologie, Hôpital National Donka, Conakry, Guinée
Fatimata Keita
Université Gamal Abdel Nasser de Conakry, Conakry, Guinée; Service de Dermatologie-Vénéréologie, Hôpital National Donka, Conakry, Guinée
Mamady Diakité
Université Gamal Abdel Nasser de Conakry, Conakry, Guinée
Mamadou Diouldé Kanté
Université Gamal Abdel Nasser de Conakry, Conakry, Guinée; Université Gamal Abdel Nasser de Conakry, Conakry, Guinée
Moussa Savané
Université Gamal Abdel Nasser de Conakry, Conakry, Guinée; Service de Dermatologie-Vénéréologie, Hôpital National Donka, Conakry, Guinée
Djibril Sylla
Université Gamal Abdel Nasser de Conakry, Conakry, Guinée; Service des Urgence Médico-Chirurgicales, Hôpital National Donka, Conakry, Guinée
Amadou Kaké
Université Gamal Abdel Nasser de Conakry, Conakry, Guinée; Service de Diabétologie et des Maladies Métaboliques, Hôpital National Donka, Conakry, Guinée
Kadiatou Diallo
Université Gamal Abdel Nasser de Conakry, Conakry, Guinée; Service de Médecine Interne, Hôpital National Donka, Conakry, Guinée
Mafoudia Touré
Service de Pédiatrie de l’Hôpital National Donka, Conakry, Guinée
Mohamed Cissé
Université Gamal Abdel Nasser de Conakry, Conakry, Guinée; Service de Dermatologie-Vénéréologie, Hôpital National Donka, Conakry, Guinée
Abstract
Introduction: children pay a heavy price for infection with the hepatitis B virus (HBV). The objective of this work was to determine the prevalence of hepatitis B and describe the associated factors in children at the Pediatric Department of Donka Hospital.
Methods: this was a cross-sectional study of a cohort of children in the Pediatric Department of Donka Hospital. HBsAg was performed by using an immunochromatographic method. The analysis of the data was done with software R. The proportions were compared using the Chi-square test or the Fisher test at the significance level of 5%. A logistic regression model was used to explain the prevalence of hepatitis B.
Results: one hundred and forty-nine children were recruited between February and July 2017. HBsAg was present in 12 children, i.e. 8.16% (95% CI: 4.29-13.82). The average age was 93.32 months (IQR: 6-180). Male children were the most affected (n = 11, P <0.05), with a sex ratio of 1.01. The majority (51.35%) were on AZT + 3TC + NVP pediatric form and 25% were on AZT + 3TC + NVP adult form and 23.65% on TDF + FTC + EFV. In univariate analysis, ALT, HBsAg positivity, and maternal HBV vaccination status were associated with the prevalence of HBsAg (P <0.05).
Conclusion: the prevalence of co-infection in children and adults is almost identical in our context. Hence the importance of strengthening preventive measures at all levels, especially the vaccination of children and mothers.
