Fabien Mukonki Kyungu
Unit of Occupational Medicine and Environmental Research, Department of Public Health, Faculty of Medicine, University of Lubumbashi, Lubumbashi, Democratic Republic of the Congo; Occupational Health and Safety Department, Kibali Gold Mine, Barrick Gold Corporation, Doko, Haut-Uélé Province, Democratic Republic of the Congo
Aude Mukonki Katumba
Department of Public Health, Faculty of Medicine, University of Lubumbashi, Lubumbashi, Democratic Republic of the Congo
Hermann Luhavo Kamwira
Occupational Health and Safety Department, Kibali Gold Mine, Barrick Gold Corporation, Doko, Haut-Uélé Province, Democratic Republic of the Congo
Aime Vonda Mayikuli
Occupational Health and Safety Department, Kibali Gold Mine, Barrick Gold Corporation, Doko, Haut-Uélé Province, Democratic Republic of the Congo
Adou Mala
Institut National de Recherche Biomédicale, Goma, Province du Nord-Kivu, République Démocratique du Congo
Manix Ilunga Banza
Department of Surgery, Faculty of Medicine, University of Lubumbashi, Lubumbashi, Democratic Republic of the Congo
Haladou Mahaman Manirou
Occupational Health and Safety Department, Barrick Gold Corporation, Bamako, Mali
Fiston Bolanda Tosali
Centre de Traitement de COVID-19, Durba, Watsa, Province du Haut-Uélé, République Démocratique du Congo
Philippe Cilundika Mulenga
Department of Public Health, Faculty of Medicine, University of Lubumbashi, Lubumbashi, Democratic Republic of the Congo
Abstract
Acute acalculous cholecystitis is an acute inflammation of the gallbladder in the absence of stones, usually occurring in elderly and critically ill patients with underlying conditions. A 29-year-old man presented to the hospital complaining of abdominal pain in the right hypochondrium with permanent fever three days after Janssen COVID-19 vaccine inoculation. Abdominal ultrasound revealed a thickened gallbladder wall without evidence of gallstone consistent of an acute acalculous cholecystitis. Blood analyses revealed thrombocytopenia, eosinophilia and liver dysfunction. The Polymerase Chain Reaction (PCR) COVID-19 test was negative. As treatment, the patient benefited of pain management, antibiotic and fluid. In the evolution, there was a regression of clinical signs with persistence of liver dysfunction. The patient was discharged ten days after hospitalization. The Janssen COVID-19 vaccine is likely to induce acute acalculous cholecystitis as adverse event following vaccination.
