Zineb Isfaoun
Mohammed V University, Pediatric Hematology and Oncology Department, Children´s Hospital in Rabat, Rabat, Morocco
Khadija Laasri
Mohammed V University, Radiology Department, Children´s Hospital in Rabat, Rabat, Morocco
Manal Jidal
Mohammed V University, Radiology Department, Children´s Hospital in Rabat, Rabat, Morocco
Nadia Cherradi
Mohammed V University, Pathology Department, Children´s Hospital in Rabat, Rabat, Morocco
Adil Melhaoui
Mohammed V University, Neurosurgery Department, Children´s Hospital in Rabat, Rabat, Morocco
Latifa Chat
Mohammed V University, Radiology Department, Children´s Hospital in Rabat, Rabat, Morocco
Siham El Haddad
Mohammed V University, Radiology Department, Children´s Hospital in Rabat, Rabat, Morocco
Maria El Kababri
Mohammed V University, Pediatric Hematology and Oncology Department, Children´s Hospital in Rabat, Rabat, Morocco
Mohamed El Khorassani
Mohammed V University, Pediatric Hematology and Oncology Department, Children´s Hospital in Rabat, Rabat, Morocco
Amina Kili
Mohammed V University, Pediatric Hematology and Oncology Department, Children´s Hospital in Rabat, Rabat, Morocco
Naoual El Ansari
Mohammed V University, Pediatric Hematology and Oncology Department, Children´s Hospital in Rabat, Rabat, Morocco
Laila Hessissen
Mohammed V University, Pediatric Hematology and Oncology Department, Children´s Hospital in Rabat, Rabat, Morocco
Abstract
Our patient had an extremely rare type of pediatric Diffuse Midline Glioma (DMG) with modified H3 K27 that occurred in the cervical spinal cord. Due to its location in the spinal cord, slow clinical presentation with torticollis for 7 months, and the non-specific radiological appearance of this tumour, it was initially considered to be a low-grade glioma. Based on imaging findings, the neurosurgery team performed a complete surgical resection, but the pathological features were consistent with a high-grade, diffuse midline glioma. Therefore, we are reporting a case of an altered high-grade DMG H3K27 glioma, which is difficult to diagnose due to its slow clinical symptoms which caused a delay in diagnosis, non-specific imaging, and with difficulty in accessing histopathological markers in low and middle income countries (LMIC).
