Giant gastric lipoma mimicking well-differentiated liposarcoma

  • Mohamed Moncef Hamdane
  • Ehsen Ben Brahim
  • Mériam belhaj Salah
  • Nooman Haouas
  • Ahmed Bouhafa
  • Achraf Chedly-Debbiche

Abstract

Authors report the case of a 51-year-old man, presenting with epigastralgia of recent onset. Physical exam was unremarkable. Endoscopy revealed a large, ulcerated, submucosal, antral tumor. CT scan reveals an antral mass with fat attenuation. The patient underwent a total gastrectomy. Macroscopic examination identified in the antral wall a 9-cm, well-circumscribed, nodular lesion, with a yellow, greasy cut surface. On histological examination, the tumor was composed of a mature adipocytes proliferation, showing significant variation in cell size, associated to some lipoblasts. Nuclei were sometimes large, slightly irregular, but without hyperchromasia nor mitosis. Diagnosis of a well-differentiated liposarcoma was suspected and molecular cytogenetic analyses showed no MDM2 nor CDK4 gene amplification on fluorescent in situ hybridization. The diagnosis of lipoma was made. Twelve months following surgery, the patient is doing well.

Pan African Medical Journal 2012; 13:16

Author Biographies

Mohamed Moncef Hamdane
Department of pathology, Habib Thameur Hospital. 8 rue Aly Ben Ayed. 1008. Montfleury, Tunis, Tunisia
Ehsen Ben Brahim
Department of pathology, Habib Thameur Hospital. 8 rue Aly Ben Ayed. 1008. Montfleury, Tunis, Tunisia
Mériam belhaj Salah
Department of pathology, Habib Thameur Hospital. 8 rue Aly Ben Ayed. 1008. Montfleury, Tunis, Tunisia
Nooman Haouas
Department of visceral surgery, Habib Thameur Hospital. 8 rue Aly Ben Ayed. 1008, Montfleury, Tunis, Tunisia
Ahmed Bouhafa
Department of visceral surgery, Habib Thameur Hospital. 8 rue Aly Ben Ayed. 1008, Montfleury, Tunis, Tunisia
Achraf Chedly-Debbiche
Department of visceral surgery, Habib Thameur Hospital. 8 rue Aly Ben Ayed. 1008, Montfleury, Tunis, Tunisia
Published
2013-02-24
Section
Articles

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eISSN: 1937-8688