Clinical and echocardiographic features of children with rheumatic heart disease and their serum cytokine profile

  • Sulafa Khalid Mohamed Ali
  • Inaam Noor Eldaim
  • Samia Hassan Osman
  • Sahar Mohamed Bakhite

Abstract

Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) constitute important public health problems in developing countries. Children with ARF and RHD seen at Children’s Hospital-Sudan from May 2008-2009 were examined clinically and by echocardiography. Blood cytokines (interleukin 10 (IL10), Tumor necrosis factor alpha (TNF- alpha) and interferon gamma (IFN-gamma) were done. Thirty six children were enrolled; 63% had established RHD, and 37% ARF. Mitral regurgitation (MR) was the most common lesion (94%).Ninety five percent of the valve lesions were severe. The serum interleukin IL10 level ranged between 3-6 pg/ml. TNF alpha levels were 9- 100 pg/ml in 12 patients (40%), 101-1000 pg/ml in 10 patients (33%) , more than 1000 in 8 patients (26%). The level of IFN gamma ranged between 2-7 pg/m in all patients except 2 (84 and 135 pg/ml). RHD is manifested with severe valvular lesions and a high TNF alpha indicating and ongoing inflammation.

Pan African Medical Journal 2012; 13:36

Author Biographies

Sulafa Khalid Mohamed Ali
Jafaar Ibn Ouf Children’s Hospital, Sudan
Inaam Noor Eldaim
Jafaar Ibn Ouf Children’s Hospital, Sudan; Department of Paediatrics and Child Health ,Faculty of Medicine, University of Khartoum, Sudan
Samia Hassan Osman
Jafaar Ibn Ouf Children’s Hospital, Sudan
Sahar Mohamed Bakhite
Department of Paediatrics and Child Health ,Faculty of Medicine, University of Khartoum, Sudan
Published
2013-02-25
Section
Articles

Journal Identifiers


eISSN: 1937-8688