Gynecologic bleeding revealing vaginal metastasis of renal cell carcinoma

  • Zineb Benbrahim
  • Ali Chouaib
  • Renaud Mazeron
  • Marie Bénédicte Leger-Ravet
  • Catherine Lefort
  • Catherine Lhommé
  • Omar El Mesbahi
  • Bernard Escudier

Abstract

Vaginal metastases of renal cell carcinoma have been rarely described. We report a case of a 75-year old woman, who underwent radical right nephrectomy for a renal cell carcinoma. Tumour was classified pT3bN0M0 and grade III of Furhmann grading. One year later, scanner discovered mediastinal and lombo-aortic lymph nodes. She received 2 months of immunotherapy associated with bevacizumab, but stopped because of intolerance. She was readmitted in our institute for vaginal bleeding. Clinical investigations showed a vaginal mass and biopsy revealed a renal cell carcinoma metastasis. This case suggests that retrograde venous dissemination may be at the origin of vaginal metastasis of renal cell carcinoma and emphasized the preventive value of early ligature of renal vein.

Pan African Medical Journal 2013; 14: 62

Author Biographies

Zineb Benbrahim
Department of medecine, Gustave Roussy Institute, France; Department of Medical Oncology, Hassan II University Hospital, Morocco
Ali Chouaib
Department of urology, Tenon Hospital, France
Renaud Mazeron
Department of medecine, Gustave Roussy Institute, France
Marie Bénédicte Leger-Ravet
Department of Pathology, Long Jumeau Hospital, France
Catherine Lefort
Department of Pathology, Long Jumeau Hospital, France
Catherine Lhommé
Department of medecine, Gustave Roussy Institute, France
Omar El Mesbahi
Department of Medical Oncology, Hassan II University Hospital, Morocco
Bernard Escudier
Department of medecine, Gustave Roussy Institute, France
Published
2013-05-04
Section
Articles

Journal Identifiers


eISSN: 1937-8688