PROMOTING ACCESS TO AFRICAN RESEARCH

Plant Products Research Journal

Log in or Register to get access to full text downloads.

Remember me or Register



DOWNLOAD FULL TEXT Open Access  DOWNLOAD FULL TEXT Subscription or Fee Access

Tolerance study of aqueous extract of Mitracarpus scaber in rabbits

D Idrissa, O Karamoko, CA Founzegue, Y Felix, AJ Djaman, JD N'guessan

Abstract


The study was to evaluate the cardiac safety of Mitracarpus scaber  (Rubiaceae) in rabbit. In this study, different batches of rabbits were injected with increasing doses of aqueous extract of Mitracarpus scaber (encoded) and changes in the activities of serum glutamic oxaloacetic transaminase (GOT), lactate deshydrogenase (LDH) and creatine phosphokinase (CPK) measured. The statistical analysis of the serum activities of these enzymes indicate a significant variation (P<0.05) of the serum activity of CPK and LDH. But there is no significant change of serum activity of GOT (P>0.05). In conclusion, the aqueous extract of Misca at dose of 100 mg/kg body weight for 4 weeks induces no cardiac dysfunction and is therefore well tolerated by the heart.

Key words: Mitracarpus scaber, heart, GOT, LDH, CPK.




AJOL African Journals Online