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Effect of aqueous extract of <i>Mangifera indica</i> on carbon tetrachloride induced liver damage of Wistar albino rats


D.T. Ebubedike
S.I. Omeodu
E.C. Ezeonwumelu

Abstract

The effect of aqueous extract of mango leaves (Mangifera indica) on carbon tetrachloride induced liver damage in wistar albino rats invitro was investigated. The liver function markers: Alanine transaminase (ALT), aspartate transaminase (AST); total protein (TP) and cholesterol were measured using standard protocols. The results showed that after the administration of carbon tetrachloride, the concentrations of ALT and AST in the serum increased with a spontaneous decrease in the total protein and cholesterol as a result of the damaged liver but on administration of varying concentrations of the extract for a period of seven days, there was a significant reduction in the concentrations of AST and ALT in the serum, while the total protein and cholesterol levels increased. The result indicated that the leaves of M. indica have hepatoprotective effect on carbon tetrachloride induced liver damage.

Keywords: quinine-imine, biuret reagent, spontaneous decrease


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eISSN: 1118-1931
print ISSN: 1118-1931