Non-IgE-mediated food allergies

  • AJ Terblanche
  • AC Lang
  • CL Gray
  • E Goddard
  • S Karabus
  • M Kriel
  • AI Manjra
  • SM Risenga
  • DA van der Spuy
  • ME Levin

Abstract

Non-imunoglobulin E (IgE)-mediated conditions include combined IgE and cell-mediated conditions such as atopic dermatitis and eosinophilic oesophagitis, and pure T-cell-mediated conditions such as food protein-induced enterocolitis syndrome, allergic proctocolitis and enteropathy syndromes. Diagnosing mixed or non-IgE-mediated allergy is challenging. A clear cause-effect relationship between exposure to the suspected food and symptoms is not always possible, as symptoms develop over time and are more chronic in nature. Skin-prick tests and specific IgE to the allergen are usually negative. An elimination diet may be necessary to diagnose non-IgE-mediated type food allergy. The suspected allergen should be excluded from the diet for 2 - 6 weeks under dietetic guidance to assess for improvement of symptoms. After symptom improvement, a rechallenge is necessary to definitively prove causal relation.

Published
2015-03-06
Section
Articles

Journal Identifiers


eISSN: 0256-95749
print ISSN: 2078-5135