Extraordinary arousal from semi-comatose state on zolpidem

  • R.P. Clauss
  • W.M. Güldenpfennig
  • H.W. Nel
  • M.M. Sathekge
  • R.R. Venkannagari

Abstract

A young semi-eomatose male patient was investigated using 99mTc hexamethyl-propylene amine oxime (99mTc HMPAO) brain single photon emission computed tomography (SPECf) before and after administration of the gamma-aminobutyric acid (GABA) agonist zolpidem. It was observed that 15 minutes after application of the drug the patient awoke from his semi-eomatose condition and remained awake for the next 3 - 4 hours. When drug action subsided he returned to his semi-eomatose state. Brain SPECf before drug application showed large hypo-active areas in certain parts of the brain. Brain SPECf after drug application showed a generalised cortical activation relative to the cerebellum and a marked and amplified activation of the areas that were hypo-active before drug application.
Published
2016-07-26
Section
Articles

Journal Identifiers


eISSN: 0256-95749
print ISSN: 2078-5135