Effects of calcium antagonists on hypertension and diastolic function

  • LH Opie
  • PJ Commerford
  • C Adnams

Abstract

Calcium antagonists are known to decrease blood pressure acutely and chronically in hypertensive patients with hypertensive heart disease, and also to improve their systolic function. However, disorders of diastolic function may occur early in hypertensive heart disease. The improvement of diastolic function by nifedipine and diltiazem is described, although it was difficult to exclude systolic unloading as a cause of the improvement. It is emphasised that diastolic dysfunction can exist in hypertensive heart disease, and that the calcium antagonists nifedipine and diltiazem can improve diastolic dysfunction.

S Afr Med J 1989; 76: 89-92

Author Biographies

LH Opie
Heart Research Unit and Cardiac Clinic, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town
PJ Commerford
Heart Research Unit and Cardiac Clinic, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town
C Adnams
Heart Research Unit and Cardiac Clinic, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town
Published
2017-08-06
Section
Articles

Journal Identifiers


eISSN: 0256-95749
print ISSN: 2078-5135