The effect of disulfiram on the urinary excretion of catecholamine metabolites in alcoholic males

  • A.H. Robins
  • J.L. Barron


The urinary -excretion of vanillylmandelic acid (VMA), homovanillic acid (HVA) and total metanephrines (TMNs) was studied in a group of White male alcoholic patients under three experimental conditions - onadmission and prior to treatment, after 7 days of administration of a placebo, and after 9 days of administration of disulfiram 400 mg/d. Disulfiram caused a significant decrease in VMA Jevels compared with the pretreatment (P<0,01) and placebo (P<0,05) levels. The output of HVA and TMNs was unchanged. It is suggested that disulf ram may produce false-negative results in cases of suspected phaeochromocytoma if VMA levels only are assayed. TMNs would appear to be the measurement of choice in such a situation.


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eISSN: 0256-95749
print ISSN: 2078-5135