Effect of Ascorbic Acid on Lipoprotein Lipase Activity

  • JP Kotze
  • MJA Matthews
  • WA De Klerk

Abstract

Baboons kept on hypovitaminotic C diets, but without clinical signs of scurvy, had significantly higher heart muscle lipoprotein lipase activity than baboons on vitamin C 34 mg/kg body mass/day. When the serum vitamin C levels were above 0,35 mg/100 ml the heart muscle lipoprotein lipase was repressed. Serum vitamin C levels below 0,35 mg/100 ml stimulated lipoprotein lipase to between 2 and 3 times the repressed value. Heart muscle lipoprotein lipase from baboons receiving dietary vitamin C was inhibited by 0,34 mM vitamin C in vitro, whereas heart muscle lipoprotein lipase from baboons on scorbutogenic diets were stimulated by addition of vitamin C in vitro.

S. Afr. Med. J., 48, 511 (1974)

Author Biographies

JP Kotze
National Research Institute for Nutritional Diseases of the South African Medical Research Council, Pretoria
MJA Matthews
National Research Institute for Nutritional Diseases of the South African Medical Research Council, Pretoria
WA De Klerk
National Research Institute for Nutritional Diseases of the South African Medical Research Council, Pretoria
Published
2017-11-05
Section
Articles

Journal Identifiers


eISSN: 0256-95749
print ISSN: 2078-5135