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South African Medical Journal

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Effect of Ascorbic Acid on Lipoprotein Lipase Activity

JP Kotze, MJA Matthews, WA De Klerk

Abstract


Baboons kept on hypovitaminotic C diets, but without clinical signs of scurvy, had significantly higher heart muscle lipoprotein lipase activity than baboons on vitamin C 34 mg/kg body mass/day. When the serum vitamin C levels were above 0,35 mg/100 ml the heart muscle lipoprotein lipase was repressed. Serum vitamin C levels below 0,35 mg/100 ml stimulated lipoprotein lipase to between 2 and 3 times the repressed value. Heart muscle lipoprotein lipase from baboons receiving dietary vitamin C was inhibited by 0,34 mM vitamin C in vitro, whereas heart muscle lipoprotein lipase from baboons on scorbutogenic diets were stimulated by addition of vitamin C in vitro.

S. Afr. Med. J., 48, 511 (1974)



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