Methyldopa combined with prindolol in the treatment of severe hypertension
AbstractIn a clinical trial of 30 patients suffering from severe hypertension (diastolic blood pressure above 130 mmHg) the combination of methyldopa and prindolol produced a satisfactory drop in blood pressure; a further 2 patients were satisfactorily controlled with the addition of furosemide 40 mg daily. Side-effects were few, and this trial was characterised by the absence of postural hypotension; this combination did not enhance central nervous system side-effects. A synergistic effect between methyldopa and β-adrenergic blocking agents as regards their hypotensive effect may exist, and the combination may be a better alternative to use than sympatholytic agents such as guanethidine or bethanidine sulphate in the treatment of severe hypertension.
S. Afr. Med. J., 48, 1608 (1974).
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