Evaluation of Azithromycin in Treatment of Acne Vulgaris Compared to
Introduction: Acne vulgaris is the most common dermatological disorder in adolescence. Treatment is essential to
prevent physical and psychological scarring. Although many treatments for acne are available, effective management
has become increasingly challenging with the emergence of antibiotic-resistant strains of Propnionibacterium acnes.
Aim: The aim of this study is to evaluate the efficacy of oral azithromycin in acne by comparing its effect with the
most common therapy used for acne; doxycycline.
Method: An opened label randomized comparative study was carried out in 40 patients of mild, moderate and Sever
acne vulgaris divided into two groups, group (A) 20 patients received azithromycin capsules in a specified and
scheduled dose regimen and group (B) 20 patients administered doxycycline tablets as a usual regimen of therapy.
Results: The results obtained from oral azithromycin therapy when compared with oral doxycycline showed that there
was statistically no difference between the two drugs in response at end of 22 weeks. The overall efficacy measured in
terms of reduction of the severity of condition was up to 83% with azithromycin compared to 50% with doxycycline.
In assessment of adverse effects and dropped-out rates the higher dropped- out rate was found in doxycycline group.
Also the patients opinion as an outcome measure confirmed that most of patients felt much better with azithromycin.
Conclusion: The conclusion from the present study is that oral azithromycin provides additionally effective and safe
treatment option to the patients, and benefits may be further extended to those patients not responding to currently
recommended antibiotic therapy.
Sudan Joural of Medical Studies Vol. 2 (1) 2007: pp. 29-31