Sudan Journal of Medical Sciences

The AJOL site is currently undergoing a major upgrade, and there will temporarily be some restrictions to the available functionality.
-- Users will not be able to register or log in during this period.
-- Full text (PDF) downloads of Open Access journal articles will be available as always.
-- Full text (PDF) downloads of subscription based journal articles will NOT be available
We apologise for any inconvenience caused. Please check back soon, as we will revert to usual policy as soon as possible.

Investigation of the effects of certain formulation factors on release properties of paracetamol tablets using 23 factorial design

A Elsayed, A Al-Badawi, AS Al-Khatim, K Mohammed


Objective: To study the effects of three formulation variables (PVP, stearic acid and Avicel PH101) on disintegration time and release properties of paracetamol tablets using a 23 factorial experimental design.
Methodology: Three formulation variables; Polyvinyl pyrrolidone (factor A), Stearic acid (factor B) and Avicel PH 101 (factor C) were used at two concentrations levels in paracetamol tablet formulation. The estimated effects of increasing the factors from a low to a high level were tested
for significance by analysis of variance. The release properties of the tablets- measured by the disintegration and the dissolution times were used as assessment parameters.
Results: Changing the concentration of factor A from” low” to “high” led to an increase in the disintegration time of the tablets. The disintegration of the tablets is not affected by factor B or C. All investigated factors in 23 factorial design had a significant effect on dissolution time. The
ranking of the factors was C > B > A.
Conclusion: The results suggest that factorial design could be useful to produce tablets with particular drug release profiles and there was a considerable interaction between the variables employed on the tablet dissolution rate.
AJOL African Journals Online