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Biochemical response of normal albino rats to the addition of aqueous leaves extract of Hibiscus cannabinus and Murraya koenigii in rats drinking water

SA James, MJ Ladan, R Auta, J Audu, A Garba


Experiments were conducted to determine the biochemical effect of Hibiscus cannabinus and Murraya koenigii extracts on normal albino rats  using standard methods. Analyses carried out indicated that the aqueous
leaf extract of H. cannabinus and M. koenigii exhibited significant  hypolipideamic activity in normal rats. Results of phytochemical studies showed that flavonoids and glycosides are the major chemical constituent of the leaf extract. Overall results indicate a significant (P<0.05) reduction of serum cholesterol, triglycerol at both concentration of 5 and 10 mg/Kg b.wt. No significant effect is seen in the hematological indices, serum glucose,  Aspartate transaminase (AST) and Alanine transaminase (ALT). The  significance of this study is thus discussed.

Key words: Hibiscus cannabinus, Murraya koenigii, flavonoid, Hypolipidemic

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