Effect of aqueous extract of <i>Anisopus manni</i> stem in alloxan-induced diabetic rats

Abstract

This study examined the effect of aqueous extract of Anisopus manni stem in alloxan-induced diabetic rats. Fifteen male rats were randomly distributed into three groups of five rats each. Normal and diabetic control groups were given distilled water. Diabetic treated group, received 400 mg/kg body weight of aqueous extract of Anisopus manni. All Administrations (oral) were carried out daily for 28 days using gavage. Fasting blood glucose and body weight were recorded at intervals of 7 days. Significant (P<0.05) increases in TG, Total cholesterol, LDL-C with significant (P<0.05) decrease in HDL-C levels were observed in diabetic control compared to normal control. Significant increase was also observed in the fasting blood glucose of diabetic control rats relative to normal control. The plant extract reverses the effects of alloxan on lipid profile levels and fasting blood glucose of diabetic treated animals. The extract exerted significant (P< 0.05) reduction in fasting blood glucose level in diabetic treated rat from week one to week three compared to diabetic control. No significant (P>0.05) effect was observed in the fourth week. The findings indicate that Anisopus mannii possess hypolipidemic and antihyperglycemic potentials.

Keywords: Alloxan, Anisopus manni, antihyperglycemic, lipid profile, rats