Formulation and in vitro evaluation of ibuprofen-loaded poly(D,L-lactide-co-glycolide) microparticles
Purpose: To enhance and control the release of ibuprofen from poly(D,L-lactide-co-glycolide) (PLGA) microparticles.
Methods: Ibuprofen-loaded microparticles containing PLGA were formulated using a
emulsification/solvent evaporation method. Various concentrations of ibuprofen (200, 300, 400 and 0 mg) were loaded into the PLGA microparticles and the formulations labeled A, B, C and D, respectively. The microcapsules were characterized for drug loading, particle size, polydispersity index, zeta potential (ZP) and drug release.
Results: The zeta potential of the microparticles were -53, -68.7, -43.1, and -37.4 mV for batches A, B, C and D, respectively. Polydispersity index ranged from 0.745 to 0.900. Encapsulation efficiency (EE %) and loading capacity (LC) ranged from 83.4 to 89.3 and 23.4 to 30.1, respectively. Maximum and minimum release of 92 and 72.0 % at 18 h were obtained for batches C and A, respectively.
Conclusion: The study shows that PLGA-loaded with ibuprofen can serve as an alternative carrier for controlled release of ibuprofen.
Keywords: Ibuprofen, Microparticles, Controlled release, Zeta potential, Polydispersity
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.