Tropical Journal of Pharmaceutical Research

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Physiochemical properties of the complex of myricetin and hydroxypropyl-β-cyclodextrin

H Nan, H Ma, R Zhang, R Zhan


Purpose: To improve the hydrophilic property of myricetin by complexing it with hydroxypropyl-β- cyclodextrin (HP-β-CD)
Methods: The complexes of myricetin and HP-β-CD were prepared in both water and ethanol. The physicochemical properties of the complex were investigated by ultraviolet-visible spectrometry (UV), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and x-ray diffractometry (XRD).
Results: The content of myricetin in the complex prepared in ethanol (3.71 %) was higher than that prepared in water (1.43 %). Characterization studies indicate that myricetin in the complex was molecularly dispersed in HP-β-CD matrix.
Conclusion: Ethanol is the better solvent to prepare the complex of myricetin and hydroxypropyl-β- cyclodextrin. Myricetin and HP-β-CD in the complex are combined by non-covalent bond, and thus did not form a new compound.

Keywords: Myricetin, Hydroxypropyl-β-cyclodextrin, Complexation, Physicochemical properties
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