Skin depigmentation activity of Crocus sativus extract cream
Purpose: To determine the antioxidant activity of Crucus sativus extract and its effect on human skin using a non-invasive probe mexameter.
Methods: The antioxidant activity of C. sativus extract was determined using DPPH method. Water in oil (w/o) topical cream of C. sativus extract (3 %) was formulated and compared with the base (cream without extract). Both creams (formulation and base) were applied to the cheeks of 10 healthy human volunteers for a period of 8 weeks. Melanin and erythema values of skin were measured with a mexameter.
Results: The antioxidant activity of the extract was 81 %. Change in the levels of skin melanin and erythema was -24.04 ± 3.23 and -13.57 ± 2.28, respectively, indicating that unlike the base, the formulation containing Crocus sativus extract produced significant (p ≤ 0.05) depigmentation and anti erythemic effect on human skin.
Conclusion: Application of the formulation containing 3 % C. sativus extract to human skin may be useful in the management of melanoma. However, further studies are still required to ascertain this.
Keywords: Antioxidant, Crocus sativus, Cream, Skin, Melanin, Erythema, Depigmentation
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