Effect of Acid Hydrolysis on Tableting Properties of Chitin Obtained from Shrimp Heads
Purpose: To assess the effect of acid hydrolysis on the degree of acetylation, crystallinity, and molecular weight of chitin obtained from shrimp heads as well as to evaluate their tableting properties.
Methods: The effect of acid hydrolysis conditions such as reaction temperature (46, 60, 80, 100, 114°C), hydrochloric acid concentration (4.6, 6, 8, 10 and 11.4 M) and reaction time (0.6, 2, 4, 6 and 7.4 h) were examined. The degree of acetylation and molecular weight were found by Fourier transform spectroscopy (FT-IR) and viscometry methods, respectively. The degree of crystallinity degree and its compact tensile strength were determined by x-ray and Fell & Newton methods, respectively.
Results: The combined effect of high temperature (> 80 oC), HCl concentration (> 2 M) and reaction time (> 4 h) led to high depolymerization, reduction in degree of acetylation, crystallinity, chitin yield and thus, decreased tensile strength and accelerated compact disintegration time. Optimal reaction conditions were achieved at an acid concentration of 2.2 M, temperature of 60 oC and reaction time of 4 h. These conditions rendered compacts with tensile strength of 25.7 MPa and disintegration time of 25.3 min.
Conclusion: The optimal HCl hydrolysis conditions for shrimp heads rendered chitin suitable for the preparation of compacts with good tensile strength and moderate disintegration time.
Keywords: Chitin, Compressibility, Deacetylation, Acid Hydrolysis, Tableting Performance, Central Composite Design
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.