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Tropical Journal of Pharmaceutical Research

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Acetyl-cholinesterase Enzyme Inhibitory Effect of Calophyllum species

Gwendoline Cheng Lian Ee, Soek Sin Teh, Siau Hui Mah, Nur Ain Jamaluddin, Muhamad Syarik bin Muhamad Sahimi, Zuraini Ahmad

Abstract


Purpose: To search for new acetylcholinesterase enzyme inhibitors from Calopyllum species.

Methods: Six stem bark extracts of Calophyllum inophyllum, C. soulattri, C. teysmannii, C. lowii, C. benjaminum and C. javanicum were subjected to anti-cholinesterase analysis against acetylcholinesterase (AChE) enzyme using Ellman’s method.

Results: Most of the extracts showed promising inhibitory activity against AChE at concentrations of 100 μg/mL, with the methanol extract of C. inophyllum demonstrating the strongest inhibitory effect of 81.28 % followed by the methanol extract of C. benjaminum with 74.32 % inhibition. The methanol extracts of Calophyllum inophyllum and Calophyllum bejaminum also showed significant inhibitory activity towards the acetylcholinesterase (AChE) enzyme.

Conclusion: Calophyllum species is capable of yielding potential lead compounds for the development for acetyl-cholinesterase enzyme inhibition drugs.

Keywords: Calophyllum species, Acetylcholinesterase, Inhibitors




http://dx.doi.org/10.4314/tjpr.v14i11.8
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