Acetyl-cholinesterase Enzyme Inhibitory Effect of Calophyllum species
Purpose: To search for new acetylcholinesterase enzyme inhibitors from Calopyllum species.
Methods: Six stem bark extracts of Calophyllum inophyllum, C. soulattri, C. teysmannii, C. lowii, C. benjaminum and C. javanicum were subjected to anti-cholinesterase analysis against acetylcholinesterase (AChE) enzyme using Ellman’s method.
Results: Most of the extracts showed promising inhibitory activity against AChE at concentrations of 100 μg/mL, with the methanol extract of C. inophyllum demonstrating the strongest inhibitory effect of 81.28 % followed by the methanol extract of C. benjaminum with 74.32 % inhibition. The methanol extracts of Calophyllum inophyllum and Calophyllum bejaminum also showed significant inhibitory activity towards the acetylcholinesterase (AChE) enzyme.
Conclusion: Calophyllum species is capable of yielding potential lead compounds for the development for acetyl-cholinesterase enzyme inhibition drugs.
Keywords: Calophyllum species, Acetylcholinesterase, Inhibitors