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Pharmacokinetic Interaction between Magnolol and Piperine in Rats

Xiao-Ying Chen
Guang-Hua Yang
Cai-Lan Li
Xiu-Ting Yu
Xiu-Fen Wang
Yi-Feng Zheng
Jian-Hui Xie
Xiao-Ping Lai
Zi-Ren Su
Yong-Zhuo Liang
Ji Lin


Purpose: To investigate the pharmacokinetic mechanism of interaction between magnolol and piperine when co-administered to rats.

Methods: The rats were divided into five groups as follows: magnolol group (625 mg/kg); low dose of piperine group (20 mg/kg); high dose of piperine group (40 mg/kg); low dose of piperine + magnolol group; or high dose of piperine + magnolol group. Plasma samples were collected at regular time intervals after administration of a single dose of magnolol (625 mg/kg, p.o.) alone or piperine (20 or 40 mg/kg, p.o.) in the presence or absence of magnolol (625 mg/kg, p.o.). The concentrations of magnolol and piperine in plasma were measured by a validated high performance liquid chromatography (HPLC) method.

Results: Compared with control, the groups given magnolol alone, concomitant administration of piperine and magnolol resulted in significant decrease (p < 0.01) in the AUC and Cmax of magnolol. Interestingly, compared with administration of piperine alone (20 mg/kg), co-administration with magnolol did not significantly (p > 0.05) alter the pharmacokinetic parameters of piperine. However, at high dose (40 mg/kg) of piperine, Cmax of piperine significantly decreased from 4.30 ± 1.47 to 2.50 ± 0.78 μg/mL (p < 0.05).

Conclusion: Co-administration of magnolol and piperine decreases plasma concentration of either drug in rats, suggesting that concurrent use of magnolol with piperine or piperine-containing diets would require close monitoring for potential interactions.

Keywords: Magnolol, Piperine, Pharmacokinetic interaction, Co administration

Journal Identifiers

eISSN: 1596-9827
print ISSN: 1596-5996