Tropical Journal of Pharmaceutical Research

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Erectile dysfunction: prevalence, risk factors and involvement of antihypertensive drugs intervention

Muhammad Salman, Naureen Shehzadi, Muhammad T Khan, Muhammad Islam, Sohail Amjad, Omer Afzal, Sibghat Mansoor, Shaista Qamar, Sohaib Peerzada, Amer H Khan, Khalid Hussain


Purpose: To explore the literature regarding prevalance, risk factors and the involvement of antihypertensive drugs in erectile dysfunction (ED).
Methods: Original research articles, reviews, editorials and case reports published in English language on the prevalence of sexual/erectile dysfunction in hypertensive men taking antihypertensive drugs and risk factors were identified through a search of four bibliographic databases, namely, PubMed, EMBASE, CINAHL and EBSCO Health.
Results: Recent analyses suggest that hypertensive men of almost all age groups suffer from ED but it is more prevalent in elderly male patients. The involvement of β-blockers was found to be controversial. Nevertheless, some evidence had been found regarding the use of propranolol in high doses.
Conclusion: The present review indicates the need for research to unravel the role of β-blockers in the manifestation of ED in hypertensive males, whom there are no contributory factors such as sedentary lifestyle, aging, stress and anxiety, etc.

Keywords: Hypertension, Antihypertensive drugs, β-Blockers, Propranolol, Erectile dysfunction, Life style, Risk factors
AJOL African Journals Online