Autophagy in photodynamic therapy

  • Liming Liang
  • Wenxiang Bi
  • Yuanyuan Tian
Keywords: Autophagy, Photodynamic therapy, Apoptosis, Cancer


Macroautophagy (autophagy) is crucial for cell survival during starvation and plays important roles in human diseases. It is a highly conserved intracellular degradation system in eukaryotes for removal and recycling of cytoplasmic components including damaged proteins and organelles to obtain energy. The relationship between cancer and autophagy has been extensively studied in recent years. In cancer and cancer therapy, autophagy acts as a double-edged sword. Photodynamic therapy (PDT) is a kind of tumor therapy applied with a tumor-localizing photosensitizing agent which is followed by activation with the light of a specific wavelength. How much is autophagy involved in photodynamic therapy? The work in this area is still limited.

Keywords: Autophagy, Photodynamic therapy, Apoptosis, Cancer


Journal Identifiers

eISSN: 1596-9827
print ISSN: 1596-5996