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Tropical Journal of Pharmaceutical Research

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Suppression of HIV-1 viral load after multiple changes in high active antiretroviral therapy: A case report

Ione Takaki, José Scoparo, Márcia A. Wingeter, Cesar Helbel, Ricardo A. Spironello, Roberto K.N. Cuman

Abstract


High active antiretroviral therapy (HAART) can reduce plasma viremia to levels below the limit of detection, leading to adequate immune recovery and clinical stability in most HIV-1-infected patients. However, the virus persists in reservoirs, and free virions can be found in the plasma. We report here the case of an HIV-infected patient diagnosed in 1999, who exhibited good adherence to medication and HAART efficacy after multiple protocol changes. In this study, we describe the clinical features, chronological changes in HIV viral load and CD4+ T-cell count, and treatment outcomes of multiple combinations of antiretrovirals (ARV).The patient presented cycles of viral load during treatment ranging from undetectable, low, and intermediate HIV-1 RNA levels, to levels above the limits of quantification. A therapeutic regimen intensified with raltegravir (RAL) promoted constant depletion of HIV viral load and an increase in CD4+ T-cells. The report shows that enhanced HAART efficacy using RAL can reduce HIV viral load.

Keywords: HAART, HIV, Viral load, Antiretroviral therapy, Raltegravir




http://dx.doi.org/10.4314/tjpr.v15i5.29
AJOL African Journals Online