Tropical Journal of Pharmaceutical Research

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Antinociceptive and anti-inflammatory properties of methanol fruit extract of Quercus incana in rat and mice models

Muhammad Saeed, Farah Gul, Zakiullah Zakiullah, Syed Naeemuddin Gilani, Yaqoob Ur Rehman, Inamullah Khan, Naveed Muhammad, Haroon Khan


Purpose: To investigate the anti-inflammatory and antinociceptive properties of crude methanol fruit extract of Quercus incana (QI), as well as its acute toxicity and phytochemical profile.

Methods: Two animal models were used: Wistar rats for carrageenan-induced paw inflammation and Swiss albino mice for acetic acid-induced writhing test (hot plate method for anti-nociceptive effect). The extract was also subjected to phytochemical screening using standard procedures.

Results: The extract showed significant (p < 0.01) anti-inflammatory effect at doses of 50, 100 and 150 mg/kg. It also evoked significant anti-nociceptive activity (both peripheral and central analgesia) at all test doses (25, 50 and 100 mg/kg; p < 0.01). Acute toxicity data revealed that the extract was non-toxic
up to a dose of 425 mg/kg, while phytochemical screening indicated the presence of alkaloids, flavonoids, steroids, terpenoids, anthraquinones, tannins, coumarins, reducing sugars and resins.

Conclusion: These results suggest that Quercus incana fruit contains compounds with antinociceptive and anti-inflammatory properties.

Keywords: Quercus incana fruit, Antinociceptive, Anti-inflammatory, Phytochemical profile
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