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Control of hyperlipidaemia, hypercholesterolaemia and hyperketonaemia by aqueous extract of Dioscorea dumetorum tuber
Abstract
Method: Wistar strain albino rats were made diabetic with the intraperitoneal administration of alloxan monohydrate. Consequently, an aqueous extract of Dioscorea dumetorum tuber was administered orally to the diabetic rats and their plasma and urine glucose, triacylglycerol, cholesterol and β-hydroxybutyrate concentrations were estimated using standard procedures. Results were compared with untreated normal and diabetic control rats. Phytochemical screening of the extract of the tuber was also carried out.
Results: Treatment with the extract significantly (p<0.05) reduced elevated blood levels of triacylglycerol, cholesterol and β–hydroxybutyrate associated with alloxan-induced diabetes mellitus. The aqueous extract tested positive for flavonoids, alkaloids, saponins and cardiac glycosides.
Conclusion: From this study, the tuber has proved not only to be an effective hypoglycaemic agent, but also possesses significant (p<0.05) hypolipidaemic and hypocholesterolaemic properties while also ameliorating ketosis.
Keywords: Alloxan, β-hydroxybutyrate, diabetes, cholesterol, Dioscorea dumetorum, triacylglycerol
Tropical Journal of Pharmaceutical Research 2003; 2(1): 183-189
