Tropical Journal of Pharmaceutical Research

Log in or Register to get access to full text downloads.

Remember me or Register

Some Physical Characteristics of Microcrystalline Cellulose Obtained from Raw Cotton of Cochlospermum planchonii

F O Ohwoavworhua, T A Adelakun


Purpose: The microcrystalline cellulose is an important ingredient in pharmaceutical, food, cosmetic and other industries. This study aimed at evaluating the physical characteristics of microcrystalline cellulose (CP-MCC), obtained from the raw cotton of Cochlospermum planchonii.

Methods: CP-MCC was obtained from the raw cotton by a two-stage sodium hydroxide treatment process followed by sodium hypochlorite bleaching and acid hydrolysis. It was examined for its physicochemical and powder properties. The powder properties of CP-MCC were compared to those of the well-known commercial microcrystalline cellulose grade, Avicel PH 101.

Results: The extraction yield of CP-MCC was approximately 21%. The cellulose material was composed of irregularly shaped fibrous cellulose particles with a moisture content of 7.2% and total ash of 0.12%. The true density was 1.38. The flow indices showed that CP-MCC has poor flow. The hydration, swelling and moisture sorption capacities were 4.7, 83.3 and 22%, respectively.

Conclusion: The cellulose product, CP-MCC, obtained from the raw cotton of Cochlospermum planchonii conformed to the official specifications in the British Pharmacopoeia (2004). The flow properties of a powder are critical in direct compression tableting; consequently, for the materials to be used for this purpose, it would require the addition of a glidant. Furthermore, the swelling parameters indicate that CP-MCC would be a better disintegrant than Avicel PH 101.

Keywords: Cochlospermum planchonii, microcrystalline cellulose, physical characteristics, pharmacopoeial requirements

> Tropical Journal of Pharmaceutical Research Vol. 4 (2) 2005: pp. 501-507
AJOL African Journals Online