Evaluation of Moringa oleifera Leaf Extract on Alcohol-induced Hepatotoxicity
A study on the protective effect of Moringa oleifera leaf extract in acute alcohol-induced hepatotoxicity in rats was evaluated. Rats fed alcohol only produced significant increase in the levels of enzyme markers of tissues damage (ALT, AST and ALP), lipid peroxidation (TBARS) and decreased serum vitamin C levels compared to normal control rats. Pretreatment with 100 and 200mg/kg body weight of extract significantly decreased the levels of enzyme markers, lipid peroxidation and markedly increased serum vitamin C level in a dose-dependent manner. Post-treatment with 200mg/kg body weight of extract significantly enhanced the recovery of animals from hepatic damage compared to untreated control. Lipid peroxidation and depletion of vitamin C due to oxidative stress could be the possible mechanisms of alcohol induced toxicity and the protective effect of the extract could be as a result of its ability to inhibit lipid peroxidation and prevent the depletion of vitamins C.
Keywords: Moringa oleifera, hepatotoxicity, lipid peroxidation, vitamin C
> Tropical Journal of Pharmaceutical Research Vol. 5 (1) 2006: pp. 539-544