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Published:
Jul 31, 2007Keywords:
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<i>In vitro </i>Antimicrobial Activity of the Extract of Mitracarpus scaber Leaves Formulated as Syrup
Abstract
Purpose: To formulate the crude extract of the leaves of Mitracarpus scarber “Zucc” as a syrup.
Method: The antimicrobial activity of the formulation was assessed using agar plates and concentrations of the extract varying between 25mg/ml and 300mg/ml to determine the minimum inhibitory concentration at 37oC against bacterial and fungal organisms namely, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Sarcina lutea, Candida albicans and Klebsiella pneumoniae.
Result: The growth of Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae and Candida albicans was inhibited by the formulation at a minimum inhibitory concentration of 75mg/ml. Pseudomonas aeruginosa, and Sarcina lutea resisted all the concentrations of the formulation used. The presence of sucrose in the formulation rendered the formulation pleasant to taste.
Conclusion: The extract from the leaves of Mitracarpus scarber “Zucc” can be formulated into a pleasantly tasting oral dosage form despite its bitter taste.
Keywords: Antimicrobial, Mitracarpus scaber, syrup, formulation, minimum inhibitory concentration
> Tropical Journal of Pharmaceutical Research Vol. 6 (1) 2007: pp. 679-682
