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Published:
Sep 27, 2007Keywords:
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Main Article Content
Antibacterial activity of the aqueous extract of <I>Thonningia sanguinea</i> against Extended-Spectrum-b-Lactamases (ESBL) producing <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> strains
Abstract
Purpose: The aim of this study was to evaluate the antimicrobial activity of Thonningia sanguinea against two sensitive and two multi-drug resistant (ESBL) Enterobacteria strains namely Escherichia coli and Klebsiella pneumoniae.
Method: The confirmation of the ESBL producing strains was done by the double-disc synergy tests and the broth dilution method was used for the determination of the antimicrobial parameters (MIC and MBC) on these sensitive and ESBL producing strains.
Results: The two sensitive strains had the same MIC and MBC values respectively 3.125 mg /ml and 12.50 mg/ml. The ESBL producing strains also had the same MIC of 6.25 mg /ml and MBC values of 25 mg/ml. The extract was bactericidal for all tested strains.
Conclusion: The results suggest that the flowers of T. sanguinea can be used in association with antibiotics for alternative therapy of diseases caused by ESBL producing E. coli, Klebsiella pneumoniae.
Keywords: Antimicrobial activity, Thonningia sanguinea, ESBL producing strains; E. coli
> Tropical Journal of Pharmaceutical Research Vol. 6 (3) 2007: pp. 779-783
