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Tropical Journal of Pharmaceutical Research

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Preparation, characterization and antibacterial effects of eco-friendly gold nanorods

Manal A Awad, Awatif A Hendi, P Virk, Khalid MO Ortashi, Mai A Elobeid, Nada M Merghani, Muzzammil I Siddiqui, EM Ibrahim

Abstract


Purpose: To synthesize and characterize eco-friendly gold nanorods (Au-NRs) and to assess their effects against two bacterial strains.
Methods: Synthesis of eco-friendly gold nanorods was done from an aqueous solution of chloroauric acid and cetyltrimethylammonium bromide by mixing Olea europaea fruit and Acacia nilotica husk extracts with the latter as a reducing agent. The synthesis was monitored by ultraviolet–visible (UV) spectrophotmetry and a zetasizer, while the morphology of the resulting nanorods was assessed by transmission electron microscopy (TEM) and scanning electron microscopy (SEM) coupled with an energy-dispersive spectrophotometer (EDS). The effect of the prepared eco-nanorods on growth of Escherichia coli and Staphylococcus aureus bacteria were investigated by agar diffusion method.
Results: The synthesized Au-NRs were mostly rod-shaped, with mean size of 96 nm. They exhibited a potent antibacterial activity against Gram-positive and  Gram-negative microorganisms (Escherichia coli and Staphylococcus aureus).
Conclusion: The findings suggest that the nanoformulation of the biomaterial mix of Olea europaea fruit and Acacia nilotica husk extracts is a cost-effective, eco-friendly, and non-toxic synthesis of Au- NRs which has therpeautic potential.

Keywords: Olea europaea, Acacia nilotica, Gold nanorods, Eco-friendly synthesis, Gram-positive and Gram-negative microorganisms




http://dx.doi.org/10.4314/tjpr.v16i2.8
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