Rice bran water extract attenuates pancreatic abnormalities in high-fat diet-induced obese rats
Purpose: To investigate the protective potential of rice bran water extract (RBE) from Khao Dawk Mali 105 on pancreatic abnormalities in high-fat diet (HFD)-induced obese rats.
Methods: Male Sprague-Dawley rats were divided into 4 groups: control group, HFD group, and HFD group treated with RBE at 2,205 or 4,410 mg/kg/day. After 4 weeks, body weight, glucose homeostatic parameters, and pancreatic fat accumulation were assessed. mRNA expression levels of sterol regulatory element-binding protein-1c (SREBP-1c), insulin receptor substrate-2 (IRS-2), glucose transporter-2 (GLUT-2) and glucokinase (GK) genes in pancreas were also analyzed.
Results: Compared with HFD group, two doses of RBE-treated rats significantly (p < 0.05) reversed HFD-induced obesity, hyperglycemia, impaired glucose tolerance and pancreatic triglyceride accumulation in rats. Histological examination of HFD-induced obese rats revealed fat droplets in acinar cells, but these alterations were ameliorated in RBE-treated rats. RBE treatment showed significantly (p < 0.05) decreased SREBP-1c expression, and also significantly (p < 0.05) increased IRS-2, GLUT-2 and GK expressions in pancreas.
Conclusion: RBE consumption may attenuate pancreatic abnormalities by inhibiting fat accumulation, as well as enhancing insulin sensitivity and glucose sensing in the pancreas of HFD-induced obese rats.
Keywords: Rice bran, Obesity, Pancreatic steatosis, Insulin signaling, Glucose sensor
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.