Preparation and physicochemical evaluation of transdermal aerosols containing ketoprofen

  • Fahimeh Ahmadi
  • Alireza Vatanara
  • Esmaeil Moazeni
  • Fatemeh Hoseini
  • Majid Darabi
Keywords: Ketoprofen, Antinucleant, Permeation enhancer, Topical aerosol, Transdermal delivery

Abstract

Purpose: To prepare transdermal ketoprofen metered-dose aerosol formulations containing menthol and isopropyl myristate (IPM) as penetration enhancers and to evaluate their physicochemical and permeation properties.

Methods: Selected ratios of ketoprofen, ethanol, polyvinylpyrrolidone K30 (PVP K30, anti-nucleant), and penetration enhancers were mixed and filled into aluminum aerosol cans with hydrofluoroalkane- 134a as propellant. The physicochemical properties of the films, and their ex vivo permeation properties in rat skin were investigated over a 24-h period. Rat skin was exposed to a definite dose of each ketoprofen film to determine the quantity of drug in the receptor compartment over a 24-h period.

Results: All the transdermal formulations showed good integrity and film uniformity. Formulations with permeation enhancers presented higher rates of skin penetration compared to control formulations. Formulations containing 3% PVP and 5% IPM produced the highest permeation rates (Jss, 85.35 μg/cm2/h).

Conclusion: These results indicate that incorporation of antinucleant polymer and permeation enhancers in aerosols containing ketoprofen enhances aerosol stability and drug permeation through rat skin.

Keywords: Ketoprofen, Antinucleant, Permeation enhancer, Topical aerosol, Transdermal delivery

Published
2017-09-06
Section
Articles

Journal Identifiers


eISSN: 1596-9827
print ISSN: 1596-5996