Association between cystatin C and the interaction of pulmonary tuberculosis with chronic diseases

  • Huan Wu
  • Jialing Xu
  • Yufeng Wen
  • Xia Dan
  • Mengxue Liu
  • Jun Ma
  • Zewei Wu
  • Hua Dong
Keywords: Cystatin C, Pulmonary tuberculosis, Chronic diseases, Inflammation

Abstract

Purpose: To determine the association between Cystatin C (Cys C) levels and the interaction of pulmonary tuberculosis (PTB) with chronic diseases (CD).

Methods: Participants (n = 356) were selected randomly from The First Affiliated Hospital of Wannan Medical College, China, and divided into 4 groups: normal control group (n = 80), PTB group (n = 98), chronic disease group (n = 146), and PTB combined with chronic disease group (PTB+CD, n = 31). The investigation included information on demographics and analysis of blood samples for Cys C, liver function, renal function, blood glucose and other biochemical indices.

Results: The highest level of Cys C was obtained in PTB + CD group. Before and after adjusting eGFR, there was no association between Cys C and PTB or/and chronic disease. However abnormal levels of Cys C were significantly higher in PTB+CD group after adjusting eGFR (OR = 4.014, p = 0.0125).

Conclusion: Higher levels of Cys C may be associated with chronic diseases co existing with PTB.

Keywords: Cystatin C, Pulmonary tuberculosis, Chronic diseases, Inflammation

Published
2017-09-07
Section
Articles

Journal Identifiers


eISSN: 1596-9827
print ISSN: 1596-5996