Prognostic value of vitamin D in patients with pneumonia: A systematic review and meta-analysis

  • Yu mei Wang
  • Chen ling Tang
  • Ming Che
  • Xiu qin Wang
  • Ai chun Li
Keywords: Pneumonia, Vitamin D, Prognosis, Meta-analysis, Systematic review

Abstract

Purpose: To investigate the prognostic role of vitamin D in pneumonia patients  through meta-analysis.

Methods: PubMed and Embase were systematically searched for relevant studies that assessed the impact of vitamin D on the risk of adverse outcomes among patients with pneumonia. Risk ratios (RR) with 95 % confidence intervals (95 % CI) were pooled using meta-analysis. Q-test and I2 statistics were used to evaluate between-study heterogeneity.

Results: Six studies were finally included in the meta-analysis. The results of meta-analysis of these studies indicated that low vitamin D status was associated with higher risk of mortality among pneumonia patients (RR = 2.59, 95 % CI = 1.32-5.08; p = 0.005). Results from meta-analysis of studies with adjusted estimates suggest that low vitamin D status was independently associated with higher risk of mortality among pneumonia patients (RR = 3.15, 95 % CI 1.54-6.44, p = 0.002). There was no significant risk of bias in the meta-analysis.

Conclusion: This study demonstrates that low vitamin D level is associated with a higher risk of adverse outcomes in patients with pneumonia.

Keywords: Pneumonia, Vitamin D, Prognosis, Meta-analysis, Systematic review

Published
2017-10-04
Section
Articles

Journal Identifiers


eISSN: 1596-9827
print ISSN: 1596-5996