Potential drug-drug interactions in the neurology ward of a tertiary care hospital in Peshawar, Pakistan
Purpose: To identify and report the prevalence of potential drug-drug interactions (pDDIs) in a neurology ward, as well as their levels and association with risk factors.
Methods: The study was conducted in the neurology ward of Northwest General Hospital Peshawar, Pakistan. Medical records of 205 randomly selected patients were retrospectively reviewed for potential drug-drug interactions using Micromedex Drug-Reax Software.
Results: The total number of interactions identified were 633. About 96 % of the patients showed at least one type of potential interaction regardless of its severity. The identified pDDIs were categorized on the basis of severity, scientific evidence and onset. Based on severity, of the total of 633 pDDIs, 62.2 % were of major type while 31.8 % were of moderate type. On the basis of scientific evidence, 16.42 % were excellent type, 32.22 % in good category while fair category was the highest (55.60 %). The onset categories such as rapid (27.64 %), delayed (24.96 %) and non-specified onset (53.71 %) were also noted.
Conclusion: Computerized DDIs programs are very helpful in minimizing harmful drug interactions. With this type of program, this better patient health outcomes can be achieved.
Keywords: Drug-drug interaction, Patients, Drug reaction
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.