PROMOTING ACCESS TO AFRICAN RESEARCH

Tropical Journal of Pharmaceutical Research

Log in or Register to get access to full text downloads.

Remember me or Register



In vitro and in vivo antitumor properties of 7-epidocetaxel, a major impurity of docetaxel

Ke Jiang, Haoran Wang, Qing Li, Ahu Yuan, Yiqiao Hu, Jinhui Wu

Abstract


Purpose: To investigate the antitumor properties and toxicity of 7-epi docetaxel (7-epi DTX) as an active pharmaceutical ingredient, and in formulations.

Methods: Docetaxel-loaded albumin nanoparticles (DTX NPs) were prepared by freeze-drying, while 7- epi DTX was detected and isolated by high performance liquid chromatography (HPLC). Their antitumor properties were evaluated in vitro in CT26 cells and in vivo in BALB/c sk-ov-3 xenograft nude mice model. The tissues were histological examined.

Results: The in vivo antitumor effects of DTX NPs at different doses of 7-epi DTX were similar. Moreover, the in vitro anti-cancer effect of 7-epi DTX was comparable to that of DTX. However, the in vivo antitumor effectiveness of 7-epi DTX was inferior to that of DTX. In toxicity studies, 7-epi DTX did not elicit any acute toxic effects both as active pharmaceutical ingredients, and as a component of formulations.

Conclusion: The results indicate that 7-epi DTX does not elicit acute toxic effects both as an active pharmaceutical ingredient and in bulk formulations. The antitumor property of 7-epi DTX is less than that of DTX.

Keywords: 7-Epidocetaxel, Impurity, Antitumor properties, Toxicity




AJOL African Journals Online