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Tropical Journal of Pharmaceutical Research

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Efficacy of combined atorvastatin calcium, Salviae miltiorrhizae and ligustrazine hydrochloride injection in cerebral infarction patients

Linlin Fu, Baojun Zhang, Xiaomin Qiu

Abstract


Purpose: To study the effect of a combination of atorvastatin calcium with Salviae miltiorrhizae and ligustrazine hydrochloride injection on serum levels of ferritin (SF), C-reactive protein (CRP) and hypoxia-inducible factor 1α(HIF-1α) in cerebral infarction patients.

Methods: A total of 60 cerebral infarction patients (confirmed by CT or MRI scan) were randomly assigned to control group and observation group (30 patients/group). Both groups received routine treatments. All patients took atorvastatin calcium, but those in the observation group were treated with Salviae miltiorrhizae and ligustrazine hydrochloride injection, in addition to atorvastatin hydrochloride for 14 days, with 7 days as treatment course. The levels of SF, CRP and HIF-1α were determined before and after treatment, to assess clinical efficacy and safety.

Results: In both groups, SF, CRP and HIF-1α levels were lower after treatment than before treatment (p < 0.05). NIHSS score and platelet activation indices were also significantly reduced, relative to control (p < 0.05).

Conclusion: The combination of atorvastatin calcium with Salviae miltiorrhizae and ligustrazine hydrochloride injection can control vascular inflammatory reactions by decreasing the levels of SF, CRP and HIF-1α. Thus, it may be beneficial in the clinical management of cerebral infarction.

Keyword: Cerebral infarction, Atorvastatin calcium, Salviae miltiorrhizae, Ligustrazine hydrochloride injection




http://dx.doi.org/10.4314/tjpr.v17i9.28
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