α-Glucosidase and α- amylase inhibition potentials of ten wild Mexican species of Verbenaceae

  • José A Ávila-Reyes
  • Norma Almaraz-Abarca
  • Eli A Delgado Alvarado
  • Rene Torres-Ricario
  • Néstor Naranjo-Jiménez
  • Marcela V Gutierrez-Velazquez
  • Laura S González-Valdez
  • José N Uribe-Soto
  • Andres Vasavilbazo-Saucedo
Keywords: Hyperglycemic, Diabetes, α-Glucosidase, α-Amylase Verbenaceae, Aloysia gratissima, Bouchea prismatica, Priva mexicana

Abstract

Purpose: To evaluate the inhibitory activity of 10 wild Verbenaceae species from Mexico against α- glucosidase and α-amylase.
Methods: Ethanol leaf extracts of 10 Verbenaceae species from Mexico were prepared. The inhibitory activity of the extracts against α-glucosidase and α-amylase was evaluated using enzymatic protocols. At least four serial diluted concentrations of each extract was used to calculate the half-maximal inhibitory concentration (IC50).
Results: The 10 evaluated Verbenaceae species showed high α-glucosidase inhibition activity, but a low inhibitory effect on α-amylase. Aloysia gratissima (IC50 = 0.122 mg/mL), Verbena carolina (IC50 = 0.112 mg/mL), Bouchea prismatica (IC50 = 0.122 mg/mL), Verbena menthiflora (IC50 = 0.071mg/mL) and Priva mexicana (IC50 = 0.032 mg/mL) exhibited the strongest inhibitory activities against α- glucosidase.
Conclusion: All the Verbenaceae species studied possess α-glucosidase inhibitory effect, with P. mexicana being the one with the strongest activity. These findings demonstrate the highs potential of these species as a source of natural antihyperglycemic agents for type 2 diabetes therapy.

Keywords: Hyperglycemic, Diabetes, α-Glucosidase, α-Amylase Verbenaceae, Aloysia gratissima, Bouchea prismatica, Priva mexicana

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eISSN: 1596-9827
print ISSN: 1596-5996