Tropical Journal of Pharmaceutical Research

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Comparative studies on the regulatory effects of raw and charred hawthorn on functional dyspepsia and intestinal flora

Zhiqiang Wei, Li Ai, Xi Chen, Lin Li, Li Wang, Wenxiang Fan, Xuekai Tang, Fang Liang, Chunjie Wu


Purpose: To compare the effects of raw hawthorn (RH) and charred hawthorn (CH) on functional dyspepsia (FD) and intestinal flora (IF).

Methods: A rat model of FD was established through use of a chronic stimulator. Rat models were evaluated by the rat’s physical state, body weight, diet, and histopathological examination. After RH or CH administration, the digestive function of the rats was evaluated by determining gastric emptying and intestinal propulsion rate, diversity of intestinal flora.

Results: RH and CH both improved gastric emptying and intestinal propulsion rate in FD group when compared to control group (p < 0.05). CH yielded higher treatment effectiveness than RH. Sixteen phyla of microbiomes were recognized from all samples. After FD model establishment, the relative abundance of Lactobacillus, Lachnospiraceae and Bacteroidales decreased compared to normal control rats. On the other hand, the relative abundance of Helicobacter and Bacteroides in the model control group increased compared to normal control. After RH and CH treatment, the relative abundance of all dysregulated phyla was restored to varying degrees, but the levels after CH treatment were similar to those of the normal control group.

Conclusion: The relative abundance of intestinal flora of FD model rats is significantly different from that of rats in normal control group. Thus, RH and CH intervention improves digestive function, and the mechanisms may be related to adjustment of gut dysbacteriosis.

Keywords: Raw Hawthorn, Charred Hawthorn, Functional dyspepsia, Intestinal flora
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