PROMOTING ACCESS TO AFRICAN RESEARCH

Tropical Journal of Pharmaceutical Research

The AJOL site is currently undergoing a major upgrade, and there will temporarily be some restrictions to the available functionality.
-- Users will not be able to register or log in during this period.
-- Full text (PDF) downloads of Open Access journal articles will be available as always.
-- Full text (PDF) downloads of subscription based journal articles will NOT be available
We apologise for any inconvenience caused. Please check back soon, as we will revert to usual policy as soon as possible.





Therapeutic efficacy of combined administration of thymosin and oxaliplatin in elderly gastric ulcer patients and its effect on cellular immunity and matrix metalloproteinase

Fang Lijuan, Li Yangfan, Zhang Lixiong

Abstract


Purpose: To investigate the clinical efficacy of thymosin combined with oxaliplatin and tiggio in aged gastric cancer (GC) sufferers, as well as their impact on cellular immunity and matrix metalloproteinase.

Methods: Elderly GC sufferers (n = 82) were divided into study and control groups by random allocation (41 patients/group). Control group was treated with oxaliplatin combined with tiggio, while the study group was treated with thymopeptide injection, in addition to oxaliplatin combined with tiggio. Each treatment course lasted 21 days, and the study involved three courses. Clinical effectiveness and toxicity in the two groups were determined and compared before and after treatment.

Results: Total effectiveness in the study group (73.16 %) and disease remission (95.11 %) were superior to the corresponding values for control patients given oxaliplatin and tiggio (48.78 and 85.37 %, respectively, p ˂ 0.05). There were markedly lower incidences of nausea, vomiting and leukopenia in the study group than in control (p ˂ 0.05).

Conclusion: The use of thymosin-oxaliplatin-tigeo triple therapy for aged GC sufferers has a definite clinical benefits and low toxic side effects.

Keywords: Thymosin, Asha Leigh Per, Teggio, Gastric cancer, Cellular immunity, Matrix metalloproteinase




http://dx.doi.org/10.4314/tjpr.v18i2.27
AJOL African Journals Online