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Methods: In this study with a pre- and post-test control group design, 30 Wistar rats were divided into six groups: Groups C1, C2, and C3 (given 1, 3, and 5 g/kg of soaked date seeds, respectively); positive control (PC, positive control given dexamethasone, 0.5 mg/kg dose), negative control (NC, edema induced by carrageenan), and healthy control (HC, no treatment). In groups C1–3, PC, and NC, carrageenan was administered intraperitoneally prior to date seed, PC and NC treatments. Prostaglandin E2 (PGE-2), cyclooxygenase (COX)-1, COX-2, interleukin (IL)-1β, and IL-12 were measured before and immdiate;y after treatment and compared between the groups.
Results: Steeped date seed modulated inflammatory mediators by decreasing IL-1β, COX-1, COX-2, IL-12, and PGE-2 significantly (p < 0.05). Its indicated that the steeped date seeds down-regulate proinflammatory mediators in a manner similar to that of dexamethasone as positive control.
Conclusion: Steeped date seeds possess anti-inflammatory activity similar to that of dexamethasone, through a mechanism involving decreases in pro-inflammatory mediators. Thus, date seeds is a potential source of herbal anti-inflammatory therapy.
Keywords: Phoenix dactylifera, Anti-inflammatory, Date seeds, Pro-inflammatory mediators, Dexamethasone